dinotefuran safari/dinotefuran insecticide/dinotefuran 20 sg CAS NO.165252-70-0

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Dinotefuran   Physical & Chemicals Properties
Common Name: Dinotefuran (ISO name)
Chemical Name: (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl) guanidine
Melting Point: 107.5° C
Water Solubility: 39.83 g/
Skin Irritation (Technical)
Slightly Irritating
Long Term Health Effects (Technical)
Dinotefuran is not a mutagen, neurotoxin reproductive toxin.

control of insect pests such as aphids,whiteflies,thrips,leafhoppers, leafminers, sawflies, mole cricket, white grubs lacebugs,

Ecological Effect
Dinotefuran is highly toxic to honeybees silkworms.
Dinotefuran is a quick-kill insecticide discovered by researchers at Mitsui Chemicals. A third generation neonicotinoid, dinotefuran was synthesized with acetycholine as the lead compound, making it different from other flea control products currently in use which are

In addition, dinotefuran does not bind to the same insect receptsites in the nerve synapse as imidacloprid other neonicotinoids. The binding is permanent causing continuous nerve stimulation death of the insect. Ingestion is not necessary. Dinotefuran kills by contact.

NOMENCLATURE
Common name dinotefuran (BSI; pa ISO)
IUPAC name (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine 
Chemical Abstracts name N-methyl-N'-nitro-N''-[(tetrahydro-3-furanyl)methyl]guanidine 
CAS RN [165252-70-0]  Development codes MTI-446 (Mitsui) 

PHYSICAL CHEMISTRY
Mol. wt. 202.2  M.f. C7H14N4O3  M.p. 94.5-101.5 °C  KOW logP = -0.644 (pH 7)  S.g./density 1.33  Solubility In purified water 54.3.3 g/l (20 °C).  pKa No dissociation in range pH 1.4 to 12.3 

APPLICATIONS
Biochemistry Agonist of the nicotinic acetylcholine receptor, affecting the synapses in the insect central nervous system.  Mode of action Active by ingestion by contact; also exhibits root-systemic activity.  Uses Controls a range of hemipterous other pests, at 100-200 g/ha. 

MAMMALIAN TOXICOLOGY
Oral Acuteal LD50 fmale rats 2804, female rats 2000, male mice 2450, female mice 2275 mg/kg.  Skin eye Acute percutaneous LD50 fmale female rats >2000 mg/kg. Not a skin sensitiser (guinea pigs). 

ECOTOXICOLOGY
Birds Acuteal LD50 fmallard ducks 1000, Japanese quail >2000 mg/kg.  Fish LC50 (96 h) fcarp >1000 ppm; (48 h) frainbow trout >40 ppm.  Daphnia (48 h) 1000 ppm  Other aquatic spp. LC50 (48 h) fcrayfish 5-10 ppm.

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